Ribocure Pharmaceuticals AB

Target group
PhD student and postdocs & researchers

About the company

Ribocure Pharmaceuticals AB is a clinical stage biotech company based in GoCo Health Innovation City in Mölndal, Gothenburg region, focused on developing cutting-edge RNA-based therapeutics. 
Our primary aim is to address significant medical needs in the fields of cardiovascular, renal, hepatic, and CNS-related diseases. We are dedicated to discovering and developing groundbreaking drug  assets using advanced oligonucleotide technologies. As a subsidiary of Ribo Life Science Co., Ltd., Ribocure benefits from a vertically integrated oligonucleotide research platform, excelling in both translational and clinical operations. Our comprehensive technological platforms cover the entire process, from sequence design, screening, and optimization to delivery technologies and large-scale commercial CMC capacity.


The project
siRNA therapeutics conjugated to N-acetylgalactosamine (GalNAc) targeting hepatocytes are well 
understood and approved for clinical use. There is significant interest in expanding the cell-specific delivery of oligonucleotides (and other drugs) beyond the liver to broaden the indications for this modality. This task is challenging, and no one has yet achieved it sufficiently.
At Ribocure Pharmaceuticals and Ribo Life Science, we have several programs exploring the 
extrahepatic delivery of siRNA or other payloads using technologies such as aptamers, small 
molecules, antibodies, nanoparticles, and peptides. We are seeking a PhD student or postdoc for a short internship at our preclinical laboratory. The work involves ranking oligosequences and 
conducting mechanistic studies of our targeted siRNA in relevant cell systems. The project will 
include both basic and advanced cell culture work, followed by analysis using methods such as 
Western blot, RT-PCR, and imaging.

The goal of this short placement is to facilitate collaboration between academia and industry, 
specifically fostering knowledge sharing between us and KI. This internship will also introduce the 
PhD student or postdoc to the work processes at a biotech and pharmaceutical company, from bench to bedside. The optimal start date for this internship is September 2025, but this can be discussed based on the selected candidate’s availability.


The candidate
We are seeking a Molecular Biologist or Cell Biologist on PhD or post doc level, with expertise in cell culturing and biochemical/molecular biology analytical methods. Preference will be given to 
candidates with experience in Metabolic Diseases or CNS biology. While knowledge of siRNA and delivery systems is advantageous, it is not mandatory. The ideal candidate should possess strong communication skills in both Swedish (preferred) and English (essential).

Contact information
Name: Hanna Wallentin, PhD, lab manager
Email: hanna.wallentin@ribocure.com
Telephone: +46 (0) 72 218 98 96

Name: Julia Grönros, PhD, Project Director External Innovation
Email: julia.gronros@ribocure.com
Telephone: +46 (0) 73 094 61 08

Company website: https://ribocure.com/