Postdoctoral Internship @ VoxlBio – Assay Development for Imaging based Spatial Transcriptomics

Target group

Postdocs and researchers (3-month project)

About VoxlBio

VoxlBio is building a next-generation spatial biology platform focused on high-throughput,
sensitive in situ transcriptomic marker detection. Our mission is to enable scalable validation
of novel spatial biomarkers, bridging the gap between discovery and translational or clinical
studies. We work closely with leading academic labs, core facilities, and industry partners to
develop and validate our technology in real world settings.

At VoxlBio, we enable robust biomarker validation to accelerate the path of precision
medicine to patients.

We are currently incubated in the KI Innovations DRIVE program in Stockholm.

The Project

This project focuses on the biochemical innovation of our platform. We are developing a
novel assay that integrates in situ hybridization chemistry with advanced signal amplification
workflows to enhance detection sensitivity without sacrificing spatial precision.
As a postdoctoral intern, you will lead the experimental optimization of this hybrid
technology. You will work closely with the R&D team to refine molecular kinetics, improve
signal-to-noise ratios in complex tissue environments, and help define the next iteration of
our commercial assay chemistry.

Key activities include:

● Design and Optimization: Iterative testing of probe architectures and amplification
protocols to maximize detection efficiency and specificity.

● Assay Integration: Developing seamless workflows that combine enzymatic steps
with chemical signal amplification.

● Tissue Validation: Applying developed assays to various biological samples (cell
pellets and tissue sections) to assess performance in "real-world" biological noise.

● Sensitivity Benchmarking: Quantitative assessment of limit-of-detection (LoD) and
dynamic range compared to existing in situ standards.

● Troubleshooting & Refinement: Identifying and resolving biochemical bottlenecks
in the assay pipeline, from fixation to signal readout.

● Documentation: Contributing to the internal "Playbook" for assay protocols to
ensure reproducibility and scalability.

Through this work, the intern will gain hands-on experience in industrial-grade biotech R&D,
taking a molecular concept from the bench toward a standardized product.

Location and time period

● Location: Karolinska Institute Campus Solna, On-site
● Duration: 3 months
● Time period: April–November 2026 (Flexible)
● Workload: Full-time

The Candidate

We are looking for a motivated and precise experimentalist with a deep understanding of
nucleic acid chemistry and a passion for building better tools for biology.
Desired background and skills:

● PhD in Molecular Biology, Biotechnology, Biochemistry, or a related field.

● Extensive experience with in situ hybridization (ISH) or imaging based spatial
transcriptomics techniques

● Strong foundation in nucleic acid detection technologies and enzymatic assays.

● Experience with fluorescence microscopy and basic image acquisition.

● A "product-oriented" mindset—you care about the robustness and reproducibility of
an assay, not just a one-off successful experiment.

● Ability to work independently in a fast-paced, collaborative lab environment.

Contact information

Project supervisor / contact:

● Name: Daniel Gyllborg
● Email: daniel@voxlbio.com
● Company website: www.voxlbio.com